The San Francisco 49ers, who won 12 games in 2025 despite losing over $95 million in salary cap value to injured players, have odds of -146 to exceed 9.5 wins in the 2026 season. Key players including Brock Purdy, Fred Warner, and Nick Bosa missed significant time last season.
Despite their success in the toughest division in football, the 49ers are the +305 third choice to win the NFC West, +960 sixth choice to win the NFC, and +1900 11th choice to win the Super Bowl for the upcoming season. catcrossgame.com
